Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Hormones of the Adrenal Glands

Hormones of the Adrenal Glands

Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...

Hormonal Regulation

Hormonal Regulation

Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.

Hormonal Regulation

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pathophysiology-Based Classification of Male Infertility: Evidence from an 800-patient Prospective Cohort.

The Journal of clinical endocrinology and metabolism·2026

Same author

Semen Quality in Transgender Individuals Seeking Fertility Preservation.

Andrology·2026

Same author

Differential effects of legacy and new-generation perfluoro-alkyl substances on in vitro differentiation and immunoglobulins production by B cells.

Environment international·2026

Same author

Body-Related Distress, Eating-Risk Indicators, and Minority Stress Correlates in Transgender and Gender-Diverse Adults: A Network Analysis.

The International journal of social psychiatry·2026

Same author

Reframing sperm cryopreservation in male cancer survivors: from procedural success to meaningful utilization.

The oncologist·2026

Same author

Vegetable Activated Charcoal for Human Consumption Reduces Selected PFAS Levels in a Bile Secretion Model: Cues on Its Possible Clinical Use.

Chemical research in toxicology·2026

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Osteoclast Derivation from Mouse Bone Marrow

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Androgens modulate osteocalcin release by human visceral adipose tissue.

Carlo Foresta¹, Giacomo Strapazzon, Luca De Toni

¹Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete CryopreservationEndocrine-Metabolic Laboratory (A.S.), Internal Medicine 3, University of PadovaEURAC Institute of Mountain Emergency Medicine (G.S.), Bozen/BolzanoDepartment of Oncological and Surgical Sciences, Clinical Surgery II (A.B), University Hospital of PadovaDepartment of Laboratory Medicine (M.P.), University Hospital of Padova, Padova, Italy.

Clinical Endocrinology

|April 28, 2011

Summary

Androgens stimulate osteocalcin (OCN) release from human adipose tissue (AT). This suggests androgens may protect energy metabolism, particularly in obesity where hormone levels are altered.

More Related Videos

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Published on: January 24, 2025

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

Related Experiment Videos

Last Updated: Jun 2, 2026

Osteoclast Derivation from Mouse Bone Marrow

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Published on: January 24, 2025

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

Area of Science:

Endocrinology
Metabolic Research
Adipose Tissue Biology

Background:

Androgens are known to inhibit fat cell differentiation and promote lipolysis.
Undercarboxylated osteocalcin (ucOCN) influences insulin and adiponectin secretion and is produced by adipose tissue.
The interplay between androgens, osteocalcin, and adipose tissue in metabolic regulation requires further elucidation.

Purpose of the Study:

To investigate the role of androgens in modulating osteocalcin (OCN) release from human adipose tissue (AT).
To examine the relationship between androgen levels, body mass index (BMI), and OCN forms in male patients.

Main Methods:

Human omental adipose tissue (OAT) was stimulated with dihydrotestosterone (DHT) in vitro, with and without flutamide.
The release of carboxylated (cOCN) and undercarboxylated (ucOCN) forms of osteocalcin by OAT was measured using ELISA.
Serum levels of total and free testosterone, ucOCN, and cOCN were measured in 91 male patients.

Main Results:

DHT stimulation significantly increased the release of both cOCN and ucOCN from OAT.
Flutamide co-incubation abolished the DHT-induced increase in OCN production.
Overweight and obese patients exhibited lower total and free testosterone, associated with reduced ucOCN and a lower ucOCN/OCN ratio.

Conclusions:

Androgens directly modulate osteocalcin release from human adipose tissue in vitro.
Androgens may offer a protective effect on energy metabolism through OCN modulation, a novel mechanism beyond their known anti-adipogenic effects.
Given altered sex hormone levels in obesity and adipose tissue's role in hormone clearance and OCN production, this interaction is particularly significant for metabolic health.