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Endogenous oestradiol but not testosterone is related to coronary artery disease in men

Emmanuela Quental Callou de Sá1, Francisco Carleial Feijó de Sá, Rebeca de Souza e Silva

  • 1Division of Endocrinology, Department of Medicine, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.

Clinical Endocrinology
|April 28, 2011
PubMed

Insights

Men with coronary artery disease (CAD) have higher oestradiol levels. This study found a positive correlation between oestradiol and CAD prevalence in men, suggesting a potential role for oestrogens in male cardiovascular disease.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Men's Health

Background:

  • Coronary artery disease (CAD) is a leading cause of death in men.
  • The role of sex hormones, particularly oestrogens, in male CAD is not well understood.
  • Testosterone's effect on male cardiovascular health is considered neutral or beneficial.

Purpose of the Study:

  • To investigate the relationship between sex hormone levels and the presence of CAD in men.
  • To explore the association of oestradiol and testosterone with coronary artery disease.

Main Methods:

  • A case-control study involving 140 men aged 40-70 undergoing coronary angiography.
  • Cases had ≥70% coronary artery occlusion; controls had ≤50% occlusion.
  • Blood analysis included total testosterone, oestradiol, and calculated free oestrogen index (FEI).

Main Results:

  • Higher oestradiol and FEI levels were positively correlated with CAD.
  • CAD prevalence was significantly higher in the highest tercile of oestradiol.
  • Testosterone levels (total, bioavailable, free) and free androgen index (FAI) did not show a significant correlation with CAD.

Conclusions:

  • Men with CAD exhibited elevated oestradiol and FEI levels.
  • Oestradiol emerged as a significant independent correlate of CAD in men.
  • Further research is required to elucidate the causal mechanisms and directionality of this association.
Abstract

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