Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ovarian Cycle01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacological Strategies for Mitigating Cytarabine-Induced Multi-Organ Toxicity: A Scoping Review on Mechanisms, Efficacy and Clinical Implications.

Cancers·2026
Same author

GDF-15: Can It Be Used as a Biomarker in Acute Cerebrovascular Incidents?

Journal of personalized medicine·2026
Same author

Alendronate for 6 or 12 months following denosumab discontinuation in women with postmenopausal osteoporosis: A prospective observational study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Osteoporosis and osteoporosis therapies as determinants of implant fixation failure in arthroplasty and spinal fusion constructs: a position statement from the Fracture Working Group of the Council of Scientific Advisors of the International Osteoporosis Foundation.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same author

Biomarkers and Their Association with Kidney Scarring After the First Episode of Febrile Urinary Tract Infection or Vesicoureteral Reflux in Pediatric Patients.

Medicina (Kaunas, Lithuania)·2026
Same author

Integrated Inflammatory Biomarker Profiling Differentiates Degrees of Body Mass Index Beyond Intestinal Barrier-Related Markers.

Cells·2026

Related Experiment Video

Updated: Jun 2, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Apelin levels in normal pregnancy.

Anargyros Kourtis1, Athina Gkiomisi, Maria Mouzaki

  • 14th Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece. argic@med.auth.gr

Clinical Endocrinology
|April 28, 2011
PubMed
Summary

In pregnancy, serum apelin levels are lower and correlate with oxidative stress markers, not insulin sensitivity. This study investigated apelin in pregnant women, finding it a potential marker for oxidative stress during gestation.

More Related Videos

Isolation of Leukocytes from the Human Maternal-fetal Interface
08:19

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Related Experiment Videos

Last Updated: Jun 2, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Isolation of Leukocytes from the Human Maternal-fetal Interface
08:19

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Area of Science:

  • Endocrinology
  • Metabolic research
  • Reproductive health

Background:

  • Apelin, an adipokine, is implicated in glucose metabolism, atherosclerosis, and oxidative stress, with elevated expression in obesity.
  • Pregnancy is characterized by physiological changes including hyperlipidemia, oxidative stress, and reduced insulin sensitivity.

Purpose of the Study:

  • To investigate serum apelin levels in human pregnancy.
  • To examine the relationship between apelin and insulin sensitivity during gestation.

Main Methods:

  • A comparative study involving 106 pregnant women and 106 age-matched non-pregnant controls.
  • Serum levels of glucose, insulin, apelin, adiponectin, lipids, and oxidized LDL were measured.
  • Body Mass Index (BMI) and Quantitative Insulin Sensitivity Check Index (QUICKI) were calculated.

Main Results:

  • Pregnant women exhibited higher BMI, serum lipids, and insulin levels, but lower serum apelin and glucose levels compared to controls.
  • Apelin showed a significant negative correlation with adiponectin in both groups.
  • In pregnant women, apelin was negatively correlated with oxidized LDL and HDL-cholesterol.

Conclusions:

  • Apelin levels are reduced in pregnancy and negatively correlate with oxidative stress markers.
  • Despite correlation with adiponectin, apelin is not a reliable marker for insulin sensitivity in pregnancy.
  • Apelin may serve as a potential biomarker for oxidative stress during human pregnancy.