Related Experiment Video
Updated: Jun 2, 2026
10:46
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
The relationship between PTH and 25-hydroxy vitamin D early in pregnancy
James E Haddow1, Louis M Neveux, Glenn E Palomaki
1Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI, USA. jhaddow@ipmms.org
Clinical Endocrinology
|April 28, 2011
Summary
The relationship between parathyroid hormone (PTH) and vitamin D (25(OH)D) is unreliable for assessing sufficiency in early pregnancy. Maternal vitamin D levels sufficient for neonates may offer a better benchmark.
Area of Science:
- Endocrinology
- Maternal-Fetal Medicine
- Nutritional Science
Background:
- Vitamin D status is crucial during pregnancy for both maternal and fetal health.
- Parathyroid hormone (PTH) levels are often used as an indicator of vitamin D status.
- The reliability of this relationship in pregnant populations requires further investigation.
Purpose of the Study:
- To measure serum PTH and 25(OH)D levels in early pregnancy.
- To examine vitamin D status in pregnant women.
- To assess the implications of these findings for maternal and fetal health.
Main Methods:
- Cross-sectional observational study design.
- Analysis of residual sera from 430 African American and 586 Caucasian women at 11-13 weeks' gestation.
- Immunoassays used for measuring serum PTH and 25-hydroxy vitamin D (25(OH)D).
Main Results:
- Significant differences in 25(OH)D concentrations between African American (47.5 nmol/l) and Caucasian (65 nmol/l) women.
- PTH levels showed no significant difference between racial groups.
- Both PTH and 25(OH)D levels varied by season and were inversely related to maternal weight.
- A weak relationship was observed between PTH and 25(OH)D levels.
Conclusions:
- The PTH/25(OH)D relationship is less reliable in early pregnancy compared to non-pregnant adults.
- Maternal 25(OH)D levels sufficient for neonatal transfer may serve as a more appropriate reference for vitamin D sufficiency.
- Further research is needed to establish optimal vitamin D guidelines during pregnancy.
More Related Videos
Related Concept Videos
01:17Hormones and Bone Tissue
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
01:23Role of Skin in Vitamin D Synthesis
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
00:59The Parathyroid Glands
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
01:21Skeleton and Calcium Homeostasis
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
01:18Functions of Thyroid Hormones
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
01:25Role of Vitamins in Maintaining Bone Health
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...