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Related Experiment Video

Updated: Jun 2, 2026

Operant Procedures for Assessing Behavioral Flexibility in Rats

Operant Procedures for Assessing Behavioral Flexibility in Rats

Published on: February 15, 2015

Phencyclidine disturbs relational memory in the transitive inference task.

Katarzyna Fijal¹, Piotr Popik

¹Behavioral Neuroscience, Institute of Pharmacology, Polish Academy of Sciencesersity, Kraków, Poland.

Behavioural Pharmacology

|April 28, 2011

Summary

This summary is machine-generated.

Subchronic phencyclidine (PCP) administration impairs transitive inference in rats, a cognitive function affected in schizophrenia. This impairment was observed shortly after PCP treatment, suggesting a link between N-methyl-D-aspartate receptor dysfunction and cognitive deficits.

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Area of Science:

Neuroscience
Cognitive Psychology
Psychopharmacology

Background:

Transitive inference, crucial for complex reasoning, is impaired in schizophrenia and prefrontal cortex-lesioned rats.
Phencyclidine (PCP), an N-methyl-D-aspartate receptor antagonist, is used to model schizophrenic symptoms.

Purpose of the Study:

To investigate the effects of subchronic PCP administration on transitive inference in rats.
To determine if PCP-induced cognitive deficits mimic those seen in schizophrenia.

Main Methods:

Rats were trained on a transitive inference task.
Subchronic PCP (2.5 mg/kg/day for 5 days) was administered.
Transitive inference performance was assessed at 3 and 10 days post-treatment.

Main Results:

Subchronic PCP administration impaired transitive inference performance.
This impairment was evident 3 days after the last PCP dose.
Cognitive deficits were no longer observed 10 days after PCP treatment.

Conclusions:

PCP administration temporarily impairs transitive inference in rats.
These findings support PCP as a pharmacological model for cognitive deficits in schizophrenia.
N-methyl-D-aspartate receptor antagonism is implicated in impaired reasoning abilities.