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Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
Published on: June 28, 2019
Association of cardiac ischemic score and coronary collateral circulation
J Arzu1, M A Siddique, F Rahman
1Department of Cardiology, Bangabandhu Sheikh Mujib Medical University, Shahbagh Dhaka, Bangladesh.
Insights
A simple cardiac ischemic score strongly predicts coronary collateral circulation in patients with coronary artery disease. This score helps identify individuals likely to have beneficial blood vessel networks that protect the heart muscle.
Area of Science:
- Cardiology
- Vascular Biology
- Medical Diagnostics
Background:
- Coronary collateral circulation is vital for maintaining myocardial perfusion in coronary atherosclerotic disease.
- Clinical indicators of cardiac ischemia, including angina and prior events, are linked to the presence of coronary collaterals.
Purpose of the Study:
- To investigate the association between a novel cardiac ischemic score and the presence of coronary collateral circulation.
- To determine if easily assessed clinical factors can predict collateral vessel development in patients with coronary artery disease.
Main Methods:
- A prospective observational cross-sectional study enrolled 128 patients with a history of cardiac ischemia indicators.
- A cardiac ischemic score (1-4) was calculated based on four clinical factors.
- Coronary collaterals were assessed using coronary angiography (Rentrop grade ≥1).
Main Results:
- Patients with coronary collaterals (Group B, Rentrop grade 1-3) predominantly had a cardiac ischemic score of 2-4 (83.3%).
- Patients without collaterals (Group A, Rentrop grade 0) mostly had a score of 1 (86.4%).
- A strong association was observed between the cardiac ischemic score and the presence of coronary collaterals.
Conclusions:
- The cardiac ischemic score is a reliable and easily applicable tool for predicting coronary collateral circulation.
- This score can aid clinicians in identifying patients who may benefit from further assessment of their collateral network.
Abstract:
Coronary collateral circulation maintains myocardial perfusion in coronary atherosclerotic disease. The indicators of cardiac ischemia, (Angina pectoris on exertion, during emotion, previous myocardial infarction and prior coronary intervention) are associated with presence of coronary collateral circulation. In this prospective observational cross sectional study, 128 patients with history of angina pectoris on exertion and or during emotion and or myocardial infarction and or previous coronary intervention were enrolled. The cardiac ischemic score (range 1-4) was calculated by adding 1 point for each of the above four clinical factors, which can be easily assessed. Presence of coronary collaterals in coronary angiogram was defined as Rentrop grade ≥1. Patients were divided into two groups. Group A patients having Rentrop grade 0 and Group B patients are with collateral circulation, having Rentrop grade 1-3. Patients having cardiac ischemic score (range 1-4) are compared in these groups. Maximum (83.3%) patients of Group B with coronary collateral circulation had cardiac ischemic score 2-4, but majority (86.4%) of Group A patients without collaterals showed the score only 1. Thus the cardiac ischemic score is strongly associated with the presence of coronary collaterals.
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