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Updated: Jun 2, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
2-[(E)-(4-Methyl-phen-yl)imino-meth-yl]-6-(morpholin-4-ylmeth-yl)phenol
Abstract:
In the title compound, C(19)H(22)N(2)O(2), the morpholine ring adopts an almost perfect normal chair conformation with puckering parameters Q(T), θ and ϕ of 0.5642 (18) Å, 177.32 (17) and ϕ = 10 (4)°, respectively. The two benzene rings make a dihedral angle of 42.67 (8)° with each other. An intra-molecular O-H⋯N hydrogen bond helps to stabilize the mol-ecular conformation. Aromatic C-H⋯π inter-actions and π-π stacking inter-actions [centroid-centroid distance = 3.6155 (15) Å] between the benzene rings contribute to the stabilization of the crystal structure.
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