Related Experiment Video
Updated: Jun 2, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
Bis(2-{2-[2-(benzyl-carbamo-yl)phen-oxy]acetamido}-eth-yl)ammonium nitrate ethanol disolvate
Jiaji Liu1, Xiaoliang Tang, Zhengdan Lu
1Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
Abstract:
In the title compound, C(36)H(40)N(5)O(6) (+)·NO(3) (-)·2C(2)H(5)OH, the nitrate anion is disordered over the two orientations of equal occupancy while the solvent mol-ecule reveals large displacement parameters. The cation is formed by protonation of the N atom of a secondary amine in the middle of the flexible chain and the whole compound has crystallographically imposed C-2 symmetry with the crystallographic b axis. An O atom of the nitrate anion links the acidic H atoms of the cation via N-H⋯O hydrogen bonding. In addition, neighbouring cations are connected by inter-molecular N-H⋯O hydrogen bonds and π-π inter-actions between the benzamide groups of the cations [centroid-centroid distance = 4.000 (3) Å], forming a chain along [001]. The ethanol solvent mol-ecules are arranged on the side of the chain through O-H⋯O hydrogen bonds.
Related Concept Videos
Electrophilic Aromatic Substitution: Nitration of Benzene
Diazonium Group Substitution: –OH and –H
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview
The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by water loss...
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism
Weak Base Solutions
2° Amines to N-Nitrosamines: Reaction with NaNO2

