[Brain-gut axis: implications on the genesis of peptic ulcer]

Clinical and laboratory evidence indicate that the brain exerts mayor control on the gastro-intestinal tract. Specific brain loci and circuits send efferent viscerotropic projections to the gut have been summarized. A variety of aminergic and peptidergic neurotransmitters have been shown specially and their function on gastric acid secretion and implications for ulcer disease. These findings suggest that ulcer disease may represents a brain-driven event, which may be the result of a neurochemical imbalance within the brain.