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Updated: Jun 2, 2026
11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N-[4-(2-Morpholino-eth-oxy)phen-yl]acetamide monohydrate
Acta Crystallographica. Section E, Structure Reports Online
|April 28, 2011
Summary
The crystal structure of a novel compound reveals sp(3) hybridized morpholine nitrogen. Molecules form infinite chains via hydrogen bonds, further stabilized by intramolecular interactions.
Area of Science:
- Crystallography
- Chemical Physics
- Materials Science
Background:
- Understanding molecular geometry and intermolecular forces is crucial in crystal engineering.
- Hydrogen bonding plays a significant role in the self-assembly of molecules in the solid state.
Purpose of the Study:
- To elucidate the crystal structure and hydrogen bonding network of the title compound, C(14)H(20)N(2)O(3)·H(2)O.
- To investigate the implications of molecular geometry on crystal packing.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the three-dimensional structure.
- Analysis of intermolecular and intramolecular interactions, including hydrogen bonds and C-H⋯O interactions.
Main Results:
- The morpholine nitrogen atom exhibits sp(3) hybridization, consistent with its chemical environment.
- Symmetry-related molecules are interconnected by a network of intermolecular hydrogen bonds (N-H⋯O, O-H⋯O, O-H⋯N).
- These hydrogen bonds result in the formation of infinite chains extending along the crystallographic b axis.
Conclusions:
- The crystal structure is characterized by a robust hydrogen bonding network that dictates the formation of one-dimensional chains.
- Intramolecular C-H⋯O interactions further stabilize the observed chain architecture.
- The study provides insights into the supramolecular assembly driven by hydrogen bonding in this specific organic compound.
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