Related Experiment Video
Updated: Jun 2, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
4-(1-Ethyl-1H-1,3-benzimidazol-2-yl)-N,N-diphenyl-aniline monohydrate
1Department of Applied Chemistry, College of Science, Nanjing University of Technology, Nanjing 210009, People's Republic of China.
Abstract:
In the title compound, C(27)H(23)N(3)O·H(2)O, the benzimidazole ring system has an r.m.s. deviation of 0.0071 Å and makes dihedral angles of 34.51 (2), 55.22 (3) and 41.05 (5)° with the central and N-bonded phenyl rings, respectively. In the crystal, the water mol-ecular is connected to the organic mol-ecule by inter-molecular O-H⋯N hydrogen bonds. Weak inter-molecular C-H⋯O hydrogen bonds also occur.
Related Concept Videos
Nomenclature of Aryl and Heterocyclic Amines
Nomenclature of Primary Amines
Diazonium Group Substitution: –OH and –H
Nomenclature of Secondary and Tertiary Amines
Preparation of Amides
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...

