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Related Experiment Video

Updated: Jun 2, 2026

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
09:02

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Published on: June 28, 2018

[Bleomycin therapy for lymphangioma].

Zs Kertész1, G Bălă, S Bancu

  • 1Chirurgie Pediatrică, U.M.F Târgu-Mureş, Romania. kzsana@yahoo.com

Chirurgia (Bucharest, Romania : 1990)
|April 29, 2011
PubMed
Summary

Intralesional bleomycin injections offer a safe and effective treatment for congenital lymphangiomas, achieving complete resolution or significant improvement in all five patients. This method avoids invasive surgery and systemic treatments, with minimal adverse effects observed.

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Area of Science:

  • Vascular Malformations
  • Pediatric Surgery
  • Oncology

Background:

  • Congenital lymphangiomas are rare lymphatic system malformations.
  • Surgical excision is the traditional treatment but has a high recurrence rate due to tissue infiltration.
  • Alternative treatments are sought for lymphangiomas where complete surgical excision is not feasible.

Observation:

  • Five patients with congenital lymphangiomas in various locations (leg, cervical, latero-thoracal) were treated.
  • Treatment involved repeated intralesional bleomycin injections at 4-week intervals, not exceeding 0.5 mg/kg.
  • Indications for treatment included lesion location and infiltration making surgery impossible.

Findings:

  • Complete resolution was observed in 4 out of 5 patients.

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Last Updated: Jun 2, 2026

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
09:02

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Published on: June 28, 2018

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
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  • Significant improvement was noted in 1 patient.
  • No additional treatments were required, and no local or general adverse effects were observed.

    • Implications:

    • Intralesional bleomycin injections present a minimally invasive, effective therapeutic option for congenital lymphangiomas.
    • This approach circumvents the need for invasive primary surgery or systemic therapies.
    • The treatment demonstrates a favorable safety profile with minimal risk of side effects compared to other methods.