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Related Experiment Video

Updated: Jun 2, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Cough pharmacotherapy: current and future status.

Peter G Gibson¹, Nicole M Ryan

¹University of Newcastle, School of Medicine and Public Health, Centre for Asthma and Respiratory Diseases, Newcastle, NSW 2308, Australia. Peter.Gibson@hnehealth.nsw.gov.au

Expert Opinion on Pharmacotherapy

|April 29, 2011

Summary

This summary is machine-generated.

New research suggests sensory neuropathic disorders may cause chronic cough. Treatments targeting transient receptor potential (TRP) channels and using neuromodulators show promise for refractory cough and hypersensitivity.

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Last Updated: Jun 2, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

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Published on: April 6, 2017

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid

Published on: January 10, 2025

Area of Science:

Respiratory Medicine
Neurology
Pharmacology

Background:

Chronic cough significantly impacts community health and quality of life, particularly refractory cough.
Upper airway hypersensitivity is a key factor in chronic cough.
Emerging treatments include neuromodulators and transient receptor potential (TRP) receptor blockers.

Purpose of the Study:

To review current evidence on chronic cough mechanisms, focusing on idiopathic/refractory cough.
To explore the role of the central nervous system and laryngeal sensory neuropathy in cough.
To investigate novel therapeutic compounds and strategies for chronic cough.

Main Methods:

Literature review of randomized controlled trials and case reports.
PubMed search focusing on idiopathic/refractory cough, central nervous system control, laryngeal irritability, sensory neuropathy, TRP receptors, and neuromodulators.
Analysis of English-language studies on chronic cough treatments.

Main Results:

Idiopathic/refractory cough may be linked to sensory neuropathic disorders.
Central nervous system regulation plays a crucial role in cough.
Compounds blocking TRP receptors and neuromodulators are under investigation for efficacy.

Conclusions:

The concept of sensory neuropathic disorder provides a framework for understanding and characterizing chronic cough.
This understanding aids in developing targeted drug therapies for chronic cough.
Neuromodulators and TRP receptor blockers represent promising avenues for managing chronic cough.