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Updated: Jun 2, 2026
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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Vitamin D treatment in primary hyperparathyroidism
Lars Rolighed1, Jens Bollerslev, Leif Mosekilde
1Department of Surgery, Aarhus University Hospital, THG, Aarhus C, Denmark. larsrolighed@gmail.com
Current Drug Safety
|April 29, 2011
Summary
Vitamin D treatment may lower parathyroid hormone levels in primary hyperparathyroidism (PHPT) patients with vitamin D insufficiency. Careful monitoring of calcium is advised due to potential increases, though evidence for benefits remains limited.
Area of Science:
- Endocrinology
- Metabolic Bone Disease
Background:
- Primary hyperparathyroidism (PHPT) and vitamin D insufficiency are common conditions.
- Vitamin D repletion is a potential treatment for concurrent PHPT and vitamin D insufficiency, but evidence is limited.
Purpose of the Study:
- To review the aspects of combined vitamin D insufficiency and PHPT.
- To evaluate the safety and outcomes of vitamin D treatment in this setting.
Main Methods:
- Literature search conducted on PubMed and Scirus.
Main Results:
- PHPT presentation may be more severe with vitamin D insufficiency.
- Vitamin D treatment might reduce PTH levels and bone turnover, potentially increasing bone mass.
- Some patients experience elevated calcium levels, necessitating vitamin D cessation or surgery.
Conclusions:
- Vitamin D assessment is crucial in PHPT.
- The cause of concurrent vitamin D insufficiency and PHPT is unclear.
- Vitamin D treatment is recommended for PHPT, potentially lowering PTH, but lacks randomized controlled trial evidence; calcium monitoring is essential for safety.
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