Related Experiment Video
Updated: Jun 2, 2026

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
Published on: July 12, 2021
Practice variability in the management of complex febrile seizures by pediatric emergency physicians and fellows
Justin W Sales1, Blake Bulloch, Mark A Hostetler
1Division of Emergency Medicine, Phoenix Children's Hospital, Phoenix, AZ, USA.
Insights
Emergency department evaluations for complex febrile seizures (CFS) in children show significant variability among physicians. Current management approaches are unclear, highlighting the need for standardized protocols and further research in pediatric emergency medicine.
Area of Science:
- Pediatric Emergency Medicine
- Neurology
Background:
- Febrile seizures are common in children, with complex febrile seizures (CFSs) posing diagnostic and management challenges.
- The emergency department (ED) evaluation and management of CFS are not well-defined, leading to potential inconsistencies in care.
Purpose of the Study:
- To assess the degree of variability in the emergency department evaluation and management of children presenting with complex febrile seizures.
Main Methods:
- An online survey was distributed to pediatric emergency medicine physicians.
- Physicians responded to five hypothetical case vignettes of children with CFS, detailing their intended diagnostic workup and disposition.
- Survey questions covered blood/urine tests, lumbar puncture, neuroimaging, hospital admission, and outpatient follow-up.
Main Results:
- A total of 353 physicians participated, predominantly attending physicians (83%).
- Significant variability was observed: 54% would order blood tests, 62% urine tests, 34% lumbar punctures, and 36% neuroimaging.
- The hypothetical hospital admission rate was 42% across vignettes.
Conclusions:
- There is substantial variability in the emergency department approach to children with complex febrile seizures.
- The optimal management strategy for CFS remains uncertain, underscoring the need for evidence-based guidelines and prospective research.
Objective:
Febrile seizures are the most common type of childhood seizure and are categorized as simple or complex. Complex febrile seizures (CFSs) are defined as events that are focal, prolonged (> 15 minutes), or recurrent. The management of CFS is poorly defined. The objective of this study was to determine the degree of variability in the emergency department evaluation of children with CFSs.
Methods:
An online survey questionnaire was developed and sent to physicians identified via the listserv of the emergency medicine section of the American Academy of Pediatrics and the pediatric emergency medicine discussion list. The questionnaire consisted of five hypothetical case vignettes describing children under 5 years of age presenting with a CFS. Following review of the first four vignettes, participants were asked if they would (1) obtain blood and urine for evaluation; (2) perform a lumbar puncture; (3) perform neurologic imaging while the child was in the emergency department; (4) admit the child to the hospital; or (5) discharge with follow-up as an outpatient, with either the primary care provider or a neurologist. The final vignette determined if antiepileptic medication would be prescribed by the physician on discharge.
Results:
Of the 353 physicians who participated, 293 (83%) were pediatric emergency medicine attending physicians and 60 (17%) were pediatric emergency medicine fellows. Overall, 54% of participants indicated that they would obtain blood for evaluation, 62% would obtain urine, 34% would perform a lumbar puncture, and 36% would perform neurologic imaging. The overall hypothetical admission rate for the case vignettes was 42%.
Conclusions:
This study indicates that extensive variability exists in the emergency department approach to patients with CFS. Our findings suggest that optimal management for CFS remains unclear and support the potential benefit of future prospective studies on this subject.
More Related Videos
09:57Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
Published on: September 20, 2024
10:23Equipment Setup and Artifact Removal for Simultaneous Electroencephalogram and Functional Magnetic Resonance Imaging for Clinical Review in Epilepsy
Published on: June 23, 2023
Related Concept Videos
Seizures l: Introduction
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Epilepsy ll: Types
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Patterns of Fever