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[MicroRNAs in pathophysiology of renal disease: an increasing interest]

Lucile Amrouche1, Raja Bonifay, Dany Anglicheau

  • 1Inserm UMR-S775, Université René Descartes, Centre universitaire des Saints- Pères, 45, rue des Saints-Pères, 75006, Paris, France.

Medecine Sciences : M/S
|April 29, 2011
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are involved in kidney development and disease. This review explores the crucial roles of miRNAs in various renal pathophysiologies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Context:

  • MicroRNAs (miRNAs) are small, noncoding RNAs regulating gene expression post-transcriptionally.
  • Emerging evidence links miRNAs to renal development and disease pathogenesis.
  • Specific roles in renal fibrogenesis, immunity, and transplantation are increasingly recognized.

Purpose:

  • To review the multifaceted implications of miRNAs in renal pathophysiology.
  • To consolidate current understanding of miRNA involvement in kidney diseases.
  • To highlight miRNAs as potential therapeutic targets in nephrology.

Summary:

  • miRNAs post-transcriptionally control gene expression by targeting messenger RNA.
  • They play significant roles in kidney development and the progression of renal diseases.
  • This includes involvement in fibrogenesis, immune responses, autoimmune conditions, and allograft rejection.

Impact:

  • Provides a comprehensive overview of miRNA functions in renal pathophysiology.
  • Establishes the significance of miRNAs in understanding and potentially treating kidney diseases.
  • Underscores the therapeutic potential of targeting miRNA pathways in renal medicine.

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