New antiplasmodial indole alkaloids from Hunteria zeylanica
Alfarius E Nugroho1, Masatomo Sugai, Yusuke Hirasawa
1Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.
Bioorganic & Medicinal Chemistry Letters
|April 29, 2011
Abstract:
Two new indole alkaloids, bisnicalaterine D (1), consisting of an eburnane and a corynanthe type of skeletons, and nicalaterine A (2) were isolated from the bark of Hunteria zeylanica. Their structures were elucidated by various spectroscopic data such as NMR and CD spectra. A series of bisnicalaterines and nicalaterine A showed potent antiplasmodial activity against Plasmodium falciparum 3D7.
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