Synthesis and properties of triazole-linked RNA
Daniel Mutisya1, Chelliah Selvam, Scott D Kennedy
1Department of Chemistry, Binghamton University, The State University of New York, Binghamton, NY 13902, USA.
Bioorganic & Medicinal Chemistry Letters
|April 29, 2011
Abstract:
RNA oligonucleotides having triazole linkages between uridine and adenosine nucleosides have been prepared and studied using spectroscopic techniques. UV melting and CD showed that triazole strongly destabilized RNA duplex (7-14°C per modification). NMR data suggested that, despite relative flexibility around the modified linkage, all base pairs were formed.
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