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Updated: Jun 2, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Transient pseudohypoaldosteronism masquerading as congenital adrenal hyperplasia
L Manikam1, M P Cornes, D Kalra
1Wolverhampton University, Wolverhampton, West Midlands, UK. logan.manikam@doctors.org.uk
Abstract:
We report a six-week-old boy with genitourinary structural abnormalities who presented with profound hyponatraemia and hyperkalaemia due to transient type 1 pseudohypoaldosteronism (PHA) precipitated by a urinary tract infection (UTI), which responded rapidly to intravenous saline and antibiotics. In infants with structural abnormalities of the urinary tract, we wish to highlight the importance of recognizing type 1 PHA and its association with a UTI since prompt and appropriate treatment rapidly corrects the associated metabolic abnormalities. Conversely, the identification of type 1 PHA in an infant should precipitate a search for a UTI and structural abnormalities of the urinary tract.
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