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Updated: Jun 2, 2026
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A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
Published on: October 20, 2016
CSF biomarkers in posterior cortical atrophy
J Seguin1, M Formaglio, A Perret-Liaudet
1Department of Biochemistry, Hôpital Neurologique, Hospices Civils de Lyon, Lyon, France.
Neurology
|April 29, 2011
Summary
Posterior cortical atrophy (PCA) typically shows Alzheimer disease (AD) biomarkers in cerebrospinal fluid (CSF). However, motor signs may indicate other conditions, highlighting CSF
Area of Science:
- Neurodegenerative diseases
- Biomarker analysis
- Neurology
Background:
- Posterior cortical atrophy (PCA) presents with visual deficits and is often linked to Alzheimer disease (AD) pathology.
- Understanding PCA's biomarker profile is crucial for accurate diagnosis and differentiation from other dementias.
Purpose of the Study:
- To characterize cerebrospinal fluid (CSF) biomarker profiles in PCA patients.
- To correlate these CSF profiles with clinical and neuropsychological assessments.
- To determine the diagnostic utility of CSF biomarkers in distinguishing AD-related PCA from other conditions.
Main Methods:
- Prospective observational study of 22 PCA patients.
- CSF analysis for total tau (t-tau), phosphorylated tau (p-tau181), and amyloid-beta (Aβ42).
- Comparison of PCA CSF profiles with typical AD and other dementia (OD) groups; individual clinical correlation.
Main Results:
- PCA group CSF profiles were similar to AD but distinct from OD (p < 0.001).
- Over 90% of PCA patients exhibited AD-consistent CSF profiles.
- PCA with visual deficits (isolated or with memory issues) predominantly showed AD biomarkers; those with motor signs were less likely to meet AD criteria.
Conclusions:
- PCA syndrome is predominantly associated with AD CSF biomarkers, aligning with neuropathological findings.
- CSF biomarkers effectively differentiate AD-related processes from non-AD conditions in PCA, particularly when motor signs suggest corticobasal syndrome.
