Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 2, 2026

Pseudofracture: An Acute Peripheral Tissue Trauma Model
10:08

Pseudofracture: An Acute Peripheral Tissue Trauma Model

Published on: April 18, 2011

Pseudofracture: an acute peripheral tissue trauma model.

Sophie S Darwiche1, Philipp Kobbe, Roman Pfeifer

  • 1Department of Surgery, University of Pittsburgh, USA.

Journal of Visualized Experiments : Jove
|April 29, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of Antithrombotics on Severely Injured Patients Over 50 With Blunt Abdominal Trauma.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026
Same author

Primary stability of uncemented standard versus intermediate revision stems in hip arthroplasty: A biomechanical in vitro study.

Clinical biomechanics (Bristol, Avon)·2026
Same author

Does the operative technique (MIPO vs. ORIF) influence surgical outcomes and complications in proximal humerus fractures? A matched-pair analysis.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026
Same author

High interobserver reliability of neutrophil phenotyping based on visual determination of CD16/CD62L expression patterns.

Langenbeck's archives of surgery·2026
Same author

Central European Sample Analysis of Traumatic Vertebral Fractures: A One-Year Retrospective Cohort Study.

Healthcare (Basel, Switzerland)·2026
Same author

Advancing pelvic and acetabular trauma education.

Archives of orthopaedic and trauma surgery·2026
Same journal

A Video Protocol of a Randomized Controlled Clinical Trial - Electrochemotherapy of Cutaneous Metastases with Reduced Dose Bleomycin (BLESS Trial).

Journal of visualized experiments : JoVE·2026
Same journal

A Standardized Ex Vivo Porcine Oromucosal Model for Evaluating Peptide Fluxes.

Journal of visualized experiments : JoVE·2026
Same journal

Lightweight English Text Classification with Deep Learning Based on Complex System Theory.

Journal of visualized experiments : JoVE·2026
Same journal

Integrating Artificial Intelligence-Assisted Translation Support into English Courses: Effects on Translation Accuracy, Perceived Stress, and Anxiety.

Journal of visualized experiments : JoVE·2026
Same journal

A Toxin-Based Counter-Selection System for Markerless Gene Deletion and High-Density Tn5 Transposon Mutagenesis in Pectobacterium brasiliense.

Journal of visualized experiments : JoVE·2026
Same journal

Seamless Multimodal Human-Robot Communication: Integration Techniques in Human-Computer Interaction.

Journal of visualized experiments : JoVE·2026
See all related articles

This study introduces a novel pseudofracture model in mice to better study immune responses after trauma. This reproducible model allows for long-term investigation of extremity trauma without anesthesia, improving research into trauma-induced immune changes.

Area of Science:

  • Immunology
  • Trauma Research
  • Animal Modeling

Background:

  • Trauma triggers early hyper-inflammatory and delayed immunosuppressive responses, increasing mortality.
  • Investigating these immune changes is crucial for understanding trauma outcomes.
  • Current murine models face challenges in long-term studies due to complex fracture fixation.

Purpose of the Study:

  • To develop and validate an easily reproducible pseudofracture model in mice.
  • To overcome limitations of existing murine trauma models for long-term immunological investigation.
  • To create a model that mimics extremity fracture while allowing animal mobility and survival.

Main Methods:

  • The pseudofracture model involves bilateral hindlimb muscle crush injury followed by injection of a bone solution.

Related Experiment Videos

Last Updated: Jun 2, 2026

Pseudofracture: An Acute Peripheral Tissue Trauma Model
10:08

Pseudofracture: An Acute Peripheral Tissue Trauma Model

Published on: April 18, 2011

  • Bone solution is prepared from crushed long bones of donor mice.
  • The model was compared to a closed femur fracture with soft tissue injury.

    • Main Results:

    • The pseudofracture model allows for long-term survival and freedom of movement.
    • It immunologically mimics an extremity fracture environment without breaking native bone.
    • The model can be combined with hemorrhagic shock for a severe multiple trauma model.

    Conclusions:

    • The pseudofracture model offers a reproducible and adaptable method for long-term trauma immunology research.
    • It provides a valuable alternative to complex fracture fixation techniques in mice.
    • This model facilitates deeper investigation into the molecular pathways of trauma-induced immune responses.