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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...

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Related Experiment Video

Updated: Jun 2, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

MicroRNA therapeutics.

J A Broderick1, P D Zamore

  • 1Program in Neuroscience, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Gene Therapy
|April 29, 2011
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are key regulators of gene expression with therapeutic potential. Further research into miRNA mechanisms and targets is crucial for developing novel anti-miRNA drugs for clinical use.

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Last Updated: Jun 2, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) play critical roles in cellular processes and development.
  • Understanding miRNA-mediated gene regulation is incomplete.
  • Existing knowledge gaps hinder the full therapeutic exploitation of miRNAs.

Purpose of the Study:

  • To highlight the significance of microRNAs as therapeutic targets.
  • To underscore the need for further investigation into miRNA molecular mechanisms.
  • To discuss the potential of anti-miRNA strategies in clinical applications.

Main Methods:

  • Review of current literature on miRNA function and regulation.
  • Analysis of recent advancements in miRNA targeting strategies.
  • Discussion of the implications for drug development.

Main Results:

  • MicroRNAs are implicated in numerous diseases, presenting therapeutic opportunities.
  • The precise mechanisms of miRNA gene regulation and their mRNA targets are not fully elucidated.
  • Progress in developing effective miRNA inhibitors shows promise for clinical translation.

Conclusions:

  • MicroRNAs represent promising targets for novel therapeutics.
  • Continued research into miRNA biology is essential for advancing clinical applications.
  • Anti-miRNA drugs are nearing clinical viability for treating various diseases.