Leser-Trélat Sign without Internal Malignancy.
1Department of Dermatology, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France.
Case Reports in Oncology
|April 29, 2011
Summary
The Leser-Trélat sign, typically linked to cancer, can appear in healthy individuals. This case study highlights its occurrence without underlying malignancy, challenging previous associations.
Area of Science:
- Dermatology
- Oncology
Background:
- The Leser-Trélat sign is a rare dermatological phenomenon.
- It is classically associated with the abrupt onset of multiple seborrheic keratoses.
- This sign is strongly linked to internal malignancy.
Observation:
- A case of Leser-Trélat sign is presented in a 66-year-old healthy woman.
- The patient exhibited the characteristic sudden eruption of multiple seborrheic keratoses.
- Initial evaluation and a 2-year follow-up revealed no evidence of underlying malignancy.
Findings:
- The presented case suggests Leser-Trélat sign can occur in individuals without internal malignancy.
- This finding contrasts with the predominant literature associating the sign with cancer.
- The case expands the known clinical spectrum of the Leser-Trélat sign.
Implications:
- Clinicians should consider benign causes or the absence of malignancy in some Leser-Trélat sign cases.
- Further research is needed to understand the pathophysiology in healthy individuals.
- This broadens the differential diagnosis for patients presenting with eruptive seborrheic keratoses.
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