Related Experiment Video

Updated: Jun 2, 2026

A Functional Assay for Gap Junctional Examination; Electroporation of Adherent Cells on Indium-Tin Oxide
11:02

A Functional Assay for Gap Junctional Examination; Electroporation of Adherent Cells on Indium-Tin Oxide

Published on: October 18, 2014

Phosphatase-resistant gap junctions inhibit pathological remodeling and prevent arrhythmias

Benjamin F Remo1, Jiaxiang Qu, Frank M Volpicelli

  • 1Leon H. Charney Division of Cardiology, New York University School of Medicine, 522 First Ave, Smilow 801, New York, NY 10016, USA.

Circulation Research
|April 30, 2011
PubMed
Summary

Connexin43 (Cx43) phosphorylation regulates cardiac gap junctions. Phosphomimetic Cx43 prevented remodeling and arrhythmias, while nonphosphorylatable Cx43 worsened them, revealing a key role in heart function.

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