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Updated: Jun 2, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

Cyclophosphamide-induced symptomatic hyponatraemia.

D M Bruining¹, E N van Roon, H de Graaf

¹Department of Internal Medicine, Medical Centre Leeuwarden, the Netherlands. Martijn.Bruining@ZNB.NL

The Netherlands Journal of Medicine

|April 30, 2011

Summary

This summary is machine-generated.

Cyclophosphamide chemotherapy can cause rare, severe hyponatremia, a dangerous drop in blood sodium. Prompt treatment of this side effect is crucial for patient recovery.

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Last Updated: Jun 2, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

Area of Science:

Oncology
Pharmacology
Nephrology

Background:

Cyclophosphamide is a widely used alkylating agent for cancer and immunosuppression.
Symptomatic hyponatremia is a rare but serious adverse effect associated with cyclophosphamide treatment.
Adjuvant chemotherapy regimens often combine multiple agents, necessitating careful monitoring for specific toxicities.

Observation:

A 64-year-old female breast cancer patient experienced severe symptomatic hyponatremia.
The complication manifested as generalized seizure and convulsions following a chemotherapy cycle.
The patient received a regimen including 5-fluorouracil, epirubicin, and cyclophosphamide.

Findings:

The patient's hyponatremia was directly linked to cyclophosphamide administration.
Serum sodium levels were corrected, leading to complete recovery without neurological sequelae.
This case highlights the potential for severe electrolyte disturbances even with standard chemotherapy protocols.

Implications:

Oncologists and healthcare providers must remain vigilant for hyponatremia in patients receiving cyclophosphamide.
Awareness of this rare complication is vital regardless of the specific indication or dosage of cyclophosphamide.
Early recognition and management of cyclophosphamide-induced hyponatremia can prevent severe morbidity and mortality.