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Related Experiment Video

Updated: Jun 2, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
09:29

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Optic neuritis.

D Pau1, N Al Zubidi, S Yalamanchili

  • 1Department of Ophthalmology, The Methodist Hospital, Houston, TX 77030, USA.

Eye (London, England)
|April 30, 2011
PubMed
Summary
This summary is machine-generated.

Optic neuritis (ON) can be isolated or linked to multiple sclerosis (MS). Neuromyelitis optica (NMO) is distinct from MS, with unique ON treatment and prognosis.

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Published on: July 29, 2015

Area of Science:

  • Neuro-ophthalmology
  • Clinical Neurology
  • Demyelinating Diseases

Background:

  • Optic neuritis (ON) presents as unilateral, subacute, painful vision loss.
  • It is often idiopathic or demyelinating in adults.
  • ON can be associated with systemic or neurological symptoms.

Purpose of the Study:

  • To provide a clinical update on optic neuritis (ON).
  • To review the association of ON with multiple sclerosis (MS).
  • To discuss the relationship between ON and neuromyelitis optica (NMO).

Main Methods:

  • Literature review using PubMed (1964-2010).
  • Included original articles, reviews, and case reports on ON, MS, and NMO.
  • Focused on epidemiology, histopathology, clinical manifestations, imaging, genetics, and treatment.

Main Results:

  • Demyelinating ON is frequently associated with MS.
  • Key studies including the ON Treatment Trial and MS treatment trials were reviewed.
  • Neuromyelitis optica (NMO) is considered a separate disorder from MS.

Conclusions:

  • Acute demyelinating ON can occur independently or with MS.
  • Typical ON evaluation requires cranial MRI.
  • ON in NMO differs from MS in treatment and prognosis.