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Published on: January 18, 2019
Expression of bcl-2 protein in nephroblastomas
D Govender1, P Harilal, L Hadley
1UNIV NATAL,DEPT PAEDIAT SURG,SCH MED,ZA-4013 DURBAN,SOUTH AFRICA.
International Journal of Oncology
|April 30, 2011
Summary
Bcl-2 immunoexpression in nephroblastomas showed no correlation with standard prognostic factors. However, it may impact survival in patients receiving pre-operative chemotherapy, warranting further investigation.
Area of Science:
- Oncology
- Pathology
Background:
- Bcl-2 protein expression is a known prognostic marker in various cancers.
- Nephroblastoma (Wilms tumor) is a common pediatric kidney cancer.
Purpose of the Study:
- To investigate the prognostic significance of bcl-2 immunoexpression in nephroblastoma.
- To correlate bcl-2 expression with clinical and pathological parameters.
Main Methods:
- Immunohistochemical staining for bcl-2 was performed on 139 nephroblastoma tissue samples.
- Analysis included correlation with histology, disease status, and stage.
- Comparison of bcl-2 expression between tumors treated with and without pre-operative chemotherapy.
Main Results:
- Bcl-2 immunoreactivity was detected in 75.5% of cases, often with heterogeneous staining.
- No significant correlation was found between bcl-2 expression and histology, disease status, or stage.
- A significant difference in bcl-2 protein levels was observed in tumors treated with pre-operative chemotherapy (P=0.002).
- In patients receiving pre-operative chemotherapy, bcl-2 positive tumors had shorter survival than bcl-2 negative tumors.
Conclusions:
- Bcl-2 immunoexpression alone does not appear to be a prognostic factor for nephroblastoma based on standard parameters.
- Pre-operative chemotherapy may influence the prognostic impact of bcl-2 expression, suggesting a potential role in treatment stratification.
- Further research is needed to validate these findings in larger cohorts.
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