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The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Related Experiment Video

Updated: Jun 2, 2026

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

[Diffuse anterior retinoblastoma].

M C Herwig¹, G B Hubbard, J R Wells

¹Emory Eye Center, L.F. Montgomery Laboratory, Emory University, BT 428, 1365 Clifton Road NE, Atlanta, Georgia 30322, USA. martina.c.herwig@emory.edu

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft

|April 30, 2011

Summary

This summary is machine-generated.

Diffuse anterior retinoblastoma, a rare childhood eye cancer variant, infiltrates the anterior segment, often masking a small retinal tumor. This case report details its clinical and histological features.

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Reconstruct Human Retinoblastoma In Vitro

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

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Last Updated: Jun 2, 2026

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

Reconstruct Human Retinoblastoma In Vitro

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

Area of Science:

Ophthalmology
Pediatric Oncology
Pathology

Background:

Retinoblastoma is the most common primary intraocular tumor in childhood.
Diffuse anterior retinoblastoma is an uncommon variant, typically affecting older children.
This variant presents with extensive anterior segment infiltration, mimicking uveitis with pseudohypopyon.

Observation:

The clinical presentation can obscure the primary retinal tumor, which may be small.
Histological examination is crucial for definitive diagnosis.
This case report focuses on the clinical and histological findings of this rare variant.

Findings:

Extensive infiltration of the anterior segment by tumor cells.
Clinical signs mimicking anterior uveitis with pseudohypopyon.
A small or undetected primary retinal focus.

Implications:

Highlights the importance of considering rare retinoblastoma variants in pediatric eye conditions.
Emphasizes the diagnostic challenges posed by diffuse anterior retinoblastoma.
Underscores the need for thorough histopathological evaluation for accurate diagnosis and treatment planning.