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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Cervical spinal cord multiple sclerosis: evaluation with 2D multi-echo recombined gradient echo MR imaging.

Matthew L White1, Yan Zhang, Kathleen Healey

  • 1Radiology Department, University of Nebraska Medical Center, Omaha, NE 68198, USA. matthewwhite@unmc.edu

The Journal of Spinal Cord Medicine
|May 3, 2011
PubMed
Summary

Multi-echo recombined gradient echo (MERGE) MRI significantly improves the detection and visualization of multiple sclerosis (MS) lesions in the cervical spinal cord compared to standard T2-weighted imaging.

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Area of Science:

  • Radiology
  • Neuroimaging
  • Medical Physics

Background:

  • Cervical spinal cord lesions in multiple sclerosis (MS) can be challenging to detect.
  • Standard T2-weighted fast spin-echo (T2WFSE) imaging has limitations in visualizing these lesions.
  • Multi-echo recombined gradient echo (MERGE) imaging offers potential for improved contrast and lesion depiction.

Purpose of the Study:

  • To qualitatively and quantitatively compare the efficacy of MERGE imaging versus T2WFSE imaging.
  • To assess the ability of MERGE imaging to depict multiple sclerosis (MS) lesions in the cervical cord.
  • To evaluate lesion conspicuity and contrast-to-noise ratio (CNR) for MS detection.

Main Methods:

  • Nineteen patients with clinically diagnosed MS underwent cervical spinal cord MRI at 3T.
  • Both MERGE and T2WFSE imaging sequences were acquired.
  • Qualitative assessment of lesion conspicuity and quantitative measurement of lesion-to-background CNR were performed.

Main Results:

  • MERGE imaging identified significantly more MS lesions (79) compared to T2WFSE imaging (46).
  • T2WFSE imaging missed 34 lesions detected by MERGE imaging.
  • MERGE imaging demonstrated markedly superior lesion conspicuity and a significantly higher lesion-to-background CNR (P < 0.001).

Conclusions:

  • MERGE imaging enhances the detection and conspicuity of MS lesions in the cervical spinal cord.
  • Axial MERGE images are recommended for the diagnosis and follow-up of cervical cord MS.
  • This technique shows promise for improving the diagnostic accuracy of MS in the cervical spine.