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The relationship between serum phosphate levels with childhood obesity and insulin resistance
Nurullah Celik1, Nesibe Andiran
1Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, Fatih University, Ankara, Turkey. celiknurullah@hotmail.com
Aim:
To investigate the relationship between serum phosphate levels with obesity and insulin resistance in childhood.
Methods:
A total of 298 children and adolescents (190 obese subjects and 108 controls) were included in the study. Serum glucose, insulin, phosphate, calcium and alkaline phosphatase levels were measured after 12 h fasting at 08:00-08:30 h. We assessed insulin sensitivity by using the HOMA-IR (homeostasis model of insulin resistance) index as a surrogate marker of insulin resistance.
Results:
Serum levels of phosphate were significantly lower in the 6- to 12-year-old obese subjects than controls (p = 0.02, p < 0.05). At the same time, there was a moderate negative correlation between serum phosphate levels and the HOMA-IR index in the 6- to 12-year-old IR (-) obese children (r = -0.26, p = 0.02).
Conclusions:
Low serum phosphate levels could contribute to the development of insulin resistance in 6- to 12-year-old obese children.
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