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Related Concept Videos

The Colloidal State01:29

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...

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Related Experiment Video

Updated: Jun 2, 2026

High-Resolution Neutron Spectroscopy to Study Picosecond-Nanosecond Dynamics of Proteins and Hydration Water
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Published on: April 28, 2022

Cluster-driven dynamical arrest in concentrated lysozyme solutions.

Frédéric Cardinaux1, Emanuela Zaccarelli, Anna Stradner

  • 1Department of Physics, University of Fribourg, Fribourg, Switzerland.

The Journal of Physical Chemistry. B
|May 3, 2011
PubMed
Summary
This summary is machine-generated.

We found that lysozyme solutions transition to a cluster-dominated fluid at intermediate densities, leading to dynamical arrest. This arrest is driven by slowing cluster motion, confirmed by multiple experimental and simulation techniques.

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Published on: March 25, 2017

Area of Science:

  • Biophysics
  • Soft Matter Physics
  • Materials Science

Background:

  • Understanding protein solution behavior is crucial for various applications.
  • Lysozyme solutions exhibit complex phase behavior influenced by protein-protein interactions.

Purpose of the Study:

  • To investigate the structural and dynamical properties of salt-free lysozyme solutions.
  • To identify the mechanism driving the observed arrest transition.

Main Methods:

  • Combined small-angle X-ray scattering (SAXS) for structural data.
  • Neutron spin echo (NSE) and rheology for dynamical and macroscopic properties.
  • Brownian dynamics simulations with an effective protein interaction potential.

Main Results:

  • An arrest transition occurs in lysozyme solutions at intermediate densities (ϕ ≳ 0.05).
  • This transition is driven by the slowing and eventual arrest of cluster motion.
  • SAXS, NSE, and simulations confirm a shift from monomer to cluster-dominated fluid, with transient clusters persisting above percolation.
  • Diffusivity diverges at ϕ ≃ 0.26, correlating with viscosity increase and dynamical arrest.

Conclusions:

  • Salt-free lysozyme solutions exhibit a density-driven arrest transition.
  • The transition is characterized by the formation and slowing of transient protein clusters.
  • Dynamical arrest across all length scales is attributed to the long-lived nature of these clusters.