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Related Experiment Video

Updated: Jun 2, 2026

Production and Targeting of Monovalent Quantum Dots
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Production and Targeting of Monovalent Quantum Dots

Published on: October 23, 2014

Targeted nuclear delivery using peptide-coated quantum dots.

Chiung-Wen Kuo1, Di-Yen Chueh, Narendra Singh

  • 1Research Center for Applied Sciences, Academia Sinica, Nankang, Taipei 115, Taiwan.

Bioconjugate Chemistry
|May 3, 2011
PubMed
Summary
This summary is machine-generated.

Nuclear localization signaling (NLS) peptides facilitate quantum dot entry into cell nuclei. Lower concentrations of NLS-conjugated quantum dots (0.08 nM) showed increased nuclear uptake, suggesting size also influences transport.

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Published on: January 17, 2019

Area of Science:

  • Biotechnology
  • Cell Biology
  • Nanotechnology

Background:

  • Core/shell quantum dots (CdSe/Zns) offer unique optical properties for biological imaging.
  • Targeted delivery of nanoparticles into specific cellular compartments remains a challenge.

Purpose of the Study:

  • To investigate the mechanism of quantum dot uptake and targeted delivery into the cell nucleus.
  • To evaluate the role of nuclear localization signaling (NLS) peptides in facilitating quantum dot nuclear transport.

Main Methods:

  • Utilized bright and photostable CdSe/Zns core/shell quantum dots conjugated with NLS peptides.
  • Employed confocal and total internal reflection microscopy to trace individual quantum dot trajectories in living cells.
  • Investigated quantum dot uptake at varying concentrations (8 nM and 0.08 nM).

Main Results:

  • NLS-peptide-coated quantum dots successfully entered the cell nucleus, unlike uncoated quantum dots which remained in the cytoplasm.
  • At 8 nM, significant aggregation of peptide-coated quantum dots led to cytoplasmic localization.
  • At a lower concentration (0.08 nM), approximately 25% of NLS-peptide-coated quantum dots reached the cell nucleus.
  • Observed nuclear entry of some non-coated quantum dots, indicating a potential role for quantum dot size.

Conclusions:

  • NLS peptides are effective in directing quantum dots to the cell nucleus.
  • Quantum dot concentration and aggregation influence cellular uptake and localization.
  • Quantum dot size may be a critical factor in nuclear transport, independent of specific targeting peptides.