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Related Experiment Video

Updated: Jun 2, 2026

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A LEOPARD mimicking ST-elevation myocardial infarction.

Rodrigo Bagur1, Olivier F Bertrand, Yoann Bataille

  • 1Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.

The American Journal of Cardiology
|May 3, 2011
PubMed
Summary
This summary is machine-generated.

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LEOPARD syndrome, a rare genetic disorder, can cause serious cardiac events like myocardial infarction, especially with severe left ventricular hypertrophy. Early recognition is crucial for managing associated cardiovascular risks.

Area of Science:

  • Cardiology
  • Medical Genetics

Background:

  • ST-segment elevation myocardial infarction (STEMI) necessitates prompt diagnosis and management.
  • Coronary artery ectasia is a non-obstructive finding that can mimic obstructive coronary artery disease.
  • Left ventricular hypertrophy (LVH) is a significant risk factor for adverse cardiac events.

Observation:

  • A 47-year-old man presented with acute anterolateral STEMI.
  • Coronary angiography revealed marked coronary artery ectasia without obstructive lesions.
  • Ventriculography and cardiovascular magnetic resonance imaging confirmed severe left ventricular hypertrophy.
  • The patient exhibited multiple lentigines, ocular hypertelorism, and sensorineural deafness.

Findings:

  • The constellation of symptoms led to the diagnosis of LEOPARD syndrome.

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  • LEOPARD syndrome (Lentigines, Electrocardiographic anomalies, Ocular hypertelorism, Pulmonary stenosis, Anomalies of the genitalia, Retarded growth, and Deafness) is a rare genetic disorder.
  • Severe left ventricular hypertrophy was a key cardiac manifestation in this case.

    • Implications:

    • LEOPARD syndrome, though uncommon, is associated with significant cardiovascular risks.
    • Recognition of LEOPARD syndrome is critical for identifying patients at risk for adverse cardiac events.
    • This case highlights the importance of a comprehensive clinical evaluation for rare genetic syndromes presenting with cardiac abnormalities.