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Related Experiment Video

Updated: Jun 2, 2026

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
06:32

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

[Medulloblastomas: review].

L Taillandier1, M Blonski, C Carrie

  • 1Unité de neuro-oncologie, service de neurologie, CHU hôpital central, 29, avenue de-Lattre-de-Tassigny, 54035 Nancy cedex, France. l.taillandier@chu-nancy.fr

Revue Neurologique
|May 3, 2011
PubMed
Summary
This summary is machine-generated.

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Medulloblastoma, a common childhood brain tumor, is treated with surgery, radiation, and chemotherapy. The goal is to improve survival rates while minimizing long-term side effects from treatment.

Area of Science:

  • Neuro-oncology
  • Pediatric oncology
  • Tumor biology

Context:

  • Medulloblastoma is the most common malignant brain tumor in children, accounting for 40% of cerebellar tumors.
  • This primitive neuro-ectodermal tumor (PNET) affects children more frequently (70-80%) than adults (20-30%).
  • Diagnosis relies on clinical, radiological, pathological, and molecular analyses.

Purpose:

  • To outline the diagnostic and treatment strategies for medulloblastoma.
  • To highlight the importance of a multidisciplinary approach in managing medulloblastoma patients.
  • To emphasize the balance between improving survival rates and mitigating treatment-related side effects.

Summary:

  • Treatment involves surgery, craniospinal radiotherapy (with exceptions for young children), and chemotherapy tailored to age and risk factors.

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Last Updated: Jun 2, 2026

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
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Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
05:10

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 3, 2010

Revealing the Ferroptotic Phenotype of Medulloblastoma
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Revealing the Ferroptotic Phenotype of Medulloblastoma

Published on: March 15, 2024

  • Medulloblastoma is a rare central nervous system tumor that is sensitive to radiation and chemotherapy.
  • Despite a good prognosis (5-year survival >75% after complete resection), long-term neurocognitive, neuroendocrine, and orthopedic sequelae can impact outcomes.

    • Impact:

    • Multidisciplinary management involving neurosurgery, neuroradiology, pediatric oncology, neuro-oncology, and radiotherapy is crucial.
    • Advances in treatment aim to enhance survival rates for medulloblastoma patients.
    • Minimizing late side effects, particularly in pediatric patients, is a key objective in medulloblastoma treatment.