Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellularity in breast carcinoma.

R A Ambros1, R C Trost

  • 1Department of Pathology, UMDNJ-New Jersey Medical School, Newark 07103.

American Journal of Clinical Pathology
|January 1, 1990
PubMed
Summary

Tumor cellularity in breast cancer correlates with lymph node involvement and mitotic figures. This cellularity mean index (CMI) provides insights into tumor aggressiveness and progression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of LY354740, a novel glutamatergic metabotropic agonist, on nonhuman primate hypothalamic-pituitary-adrenal axis and noradrenergic function.

CNS spectrums·2004
Same author

Response of adolescent bonnet macaques to an acute fear stimulus as a function of early rearing conditions.

Developmental psychobiology·2001
Same author

Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations.

Psychiatry research·2000
Same author

Simple hyperplasia of the endometrium: an evaluation of proliferative activity by Ki-67 immunostaining.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists·2000
Same author

Villoglandular adenocarcinoma of the endometrium.

The American journal of surgical pathology·2000
Same author

HER-2/neu oncogene amplification by fluorescence in situ hybridization in epithelial tumors of the ovary.

American journal of clinical pathology·1999

Area of Science:

  • Oncology
  • Pathology
  • Biomedical Engineering

Background:

  • Infiltrating ductal carcinoma is a common breast cancer subtype.
  • Understanding tumor characteristics is crucial for prognosis.
  • Tumor cellularity is a potential indicator of tumor behavior.

Purpose of the Study:

  • To investigate the correlation of tumor cellularities with various features in breast cancer.
  • To define and analyze the cellularity mean index (CMI).
  • To explore the relationship between CMI, lymph node involvement, and mitotic activity.

Main Methods:

  • Analysis of 23 consecutive cases of infiltrating ductal carcinoma.
  • Calculation of the cellularity mean index (CMI) as the percentage of tumor volume occupied by invasive tumor cells.
  • Correlation analysis with morphometric, pathologic, and clinical features, including lymph node status and mitotic figures.

Main Results:

  • CMI significantly correlated with lymph node involvement (P = 0.03).
  • CMI showed a strong correlation with the number of mitotic figures (P = 0.0002).
  • CMI also correlated with mitotic activity when adjusted for cellularity differences (P = 0.01).

Conclusions:

  • Tumor cellularity, quantified by CMI, is a significant factor in breast cancer.
  • CMI serves as a valuable indicator for predicting lymph node metastasis and tumor proliferation.
  • Further research into the relationship between cellularity and mitotic activity is warranted.

Related Experiment Videos