A meta-analysis of diffusion tensor imaging studies of the corpus callosum in schizophrenia

The corpus callosum has been hypothesized to play an important role in neurobiological models of schizophrenia. Diffusion tensor imaging studies have provided evidence for a disruption in corpus callosum morphology in schizophrenia, but the regional distribution of abnormalities is not well known.

We conducted 2 meta-analyses investigating the genu and splenium of the corpus callosum in schizophrenia, respectively, based on published diffusion tensor imaging studies that employed a region-of-interest approach. Seven studies investigating the genu and splenium involving a total of 202 patients with schizophrenia and 213 healthy volunteers were included.

The meta-analysis of the genu yielded an effect size of 0.223 and was not statistically significant. The second meta-analysis investigating the splenium yielded a modest effect size of 0.527 (p=0.001), indicating that patients had lower fractional anisotropy in this region compared to healthy volunteers. Studies that included fewer men had a larger effect size for the splenium.

These findings implicate an abnormality involving the splenium of the corpus callosum in the neurobiology of schizophrenia as inferred by diffusion tensor imaging. A defect in the splenium could contribute to abnormalities in posterior interhemispheric connectivity in patients, including regions of the heteromodal association cortex.