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Updated: Jun 2, 2026

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

Engineered cardiac tissues.

Rohin K Iyer¹, Loraine L Y Chiu, Lewis A Reis

¹Institute of Biomaterials and Biomedical Engineering, 164 College St., Rosebrugh Building, University of Toronto, Toronto, Ontario, Canada M5S 3G9.

Current Opinion in Biotechnology

|May 3, 2011

Summary

This summary is machine-generated.

Cardiac tissue engineering advances promise functional heart replacements and drug screening tools. Recent progress includes cell-scaffold methods, bioreactors, stem cells, and decellularization techniques for cardiac repair.

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Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

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Last Updated: Jun 2, 2026

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

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Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair

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Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Published on: June 2, 2023

Area of Science:

Biomedical Engineering
Regenerative Medicine
Developmental Biology

Background:

Cardiac tissue engineering aims to create functional cardiac tissue for treating heart failure and for drug discovery.
Significant interdisciplinary progress has been made over the last decade.
Key contributing fields include stem cell biology, biomaterials, and genetic engineering.

Purpose of the Study:

To review recent advancements in cardiac tissue engineering.
To highlight novel approaches and their potential applications.
To discuss persistent challenges in the field.

Main Methods:

Review of classical cell-scaffold approaches.
Analysis of advanced bioreactor designs.
Examination of cell sheet engineering, whole organ decellularization, and stem cell-based strategies.
Discussion of topographical control for tissue organization.

Main Results:

Significant progress has been achieved across various cardiac tissue engineering methodologies.
Novel techniques like decellularization and advanced bioreactors are emerging.
Stem cell-based approaches show great potential for cardiac regeneration.

Conclusions:

Cardiac tissue engineering is rapidly advancing with diverse innovative techniques.
Challenges remain in stem cell-derived cardiac patch maturation and vascularization.
Continued interdisciplinary research is crucial for clinical translation.