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Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
Published on: March 3, 2015
NMR evaluation of interactions between substituted-indole and PDZ1 domain of PSD-95
Alexandre Vogrig1, Benjamin Boucherle, Hemantkumar Deokar
1Clermont Université, UBP, EA 987, LCHG, BP 10448, F-63000 Clermont-Ferrand, France.
Bioorganic & Medicinal Chemistry Letters
|May 3, 2011
Abstract:
We synthesized small organic molecules designed as PDZ ligands. These indole-based compounds were evaluated for their interaction with the PDZ1 domain of the post-synaptic density 95 (PSD-95) protein. Three molecules were found to interact with the targeted PDZ protein by NMR. One of them showed chemical shift perturbations closely related to the natural ligands.
