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Updated: Jun 2, 2026

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells
Published on: June 9, 2020
In vitro studies of cellular response to DNA damage induced by boron neutron capture therapy
M Perona1, O Pontiggia, M Carpano
1Department of Radiobiology, National Atomic Energy Commission (CNEA), San Martin, Argentina.
Abstract:
The aim of these studies was to evaluate the mechanisms of cellular response to DNA damage induced by BNCT. Thyroid carcinoma cells were incubated with (10)BPA or (10)BOPP and irradiated with thermal neutrons. The surviving fraction, the cell cycle distribution and the expression of p53 and Ku70 were analyzed. Different cellular responses were observed for each irradiated group. The decrease of Ku70 in the neutrons +BOPP group could play a role in the increase of sensitization to radiation.
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