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Updated: Jun 2, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Plasmablastic lymphoma clinically presenting in the urinary tract.

Jean-Christophe Tille¹, Marie-Françoise Pelte, Julien Schwartz

¹Department of Genetics and Laboratory Medicine, Division of Clinical Pathology, University Hospital of Geneva, 1211 Geneva 4, Switzerland. jean-christophe.tille@hcuge.ch

Annals of Diagnostic Pathology

|May 3, 2011

Summary

Plasmablastic lymphoma, a rare B-cell cancer, can affect the urinary tract, presenting diagnostic challenges. This study highlights two cases, one in an HIV-positive and one in an HIV-negative patient, both with hydronephrosis.

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Last Updated: Jun 2, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Area of Science:

Oncology
Pathology
Urology

Background:

Plasmablastic lymphoma is an aggressive B-cell neoplasm often associated with human immunodeficiency virus (HIV).
This lymphoma typically presents in the oral cavity but can occur in extranodal sites.
It poses significant diagnostic difficulties and is linked to a poor prognosis.

Observation:

Two cases of plasmablastic lymphoma involving the urinary tract are presented.
Both cases manifested with hydronephrosis, indicating urinary tract obstruction.
One patient was HIV-positive and the other was HIV-negative.

Findings:

The case in the HIV-positive patient showed a MYC translocation.
No translocation was detected in the HIV-negative patient.
These findings suggest potential differences in the molecular pathology of plasmablastic lymphoma based on HIV status.

Implications:

Urinary tract plasmablastic lymphoma is a rare but critical diagnosis to consider, especially with presenting hydronephrosis.
The presence or absence of MYC translocations may influence understanding and management strategies.
Further research is needed to elucidate the pathogenesis and optimize treatment for this challenging malignancy.