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Related Concept Videos

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Bone Marrow Sampling and Transplants

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Updated: Jun 2, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

[Hematologic malignant complications after transplantation].

Sophie Caillard1, Olivier Imhoff, Bruno Moulin

  • 1Service de néphrologie-transplantation, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France. sophie.caillard@chru-strasbourg.fr

Nephrologie & Therapeutique
|May 3, 2011
PubMed
Summary
This summary is machine-generated.

Post-transplant hemopathies, including lymphoma and myeloma, are serious organ transplant complications. Epstein-Barr virus and immunosuppression are key factors, necessitating careful monitoring and tailored treatments for better outcomes.

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Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

Area of Science:

  • Hematology
  • Oncology
  • Transplantation Medicine

Context:

  • Post-transplant hemopathies are significant complications following organ transplantation.
  • These conditions encompass non-Hodgkin lymphoma, Hodgkin disease, and myeloma.
  • Understanding their distinct yet overlapping features is crucial.

Purpose:

  • To review the pathophysiology, clinical presentation, histology, treatment, and evolution of post-transplant hemopathies.
  • To highlight the central roles of Epstein-Barr virus (EBV) and immunosuppression in lymphomagenesis.
  • To discuss management strategies, including monitoring EBV replication and therapeutic interventions.

Summary:

  • Lymphoma development is linked to EBV infection/reactivation and suppressed T-cell immunity.
  • Post-transplant lymphoproliferations are primarily treated with immunotherapy and chemotherapy.
  • Hodgkin disease and myeloma are rare, with management similar to immunocompetent patients.
  • Myeloma recurrence is frequent, requiring monitoring of monoclonal components before transplantation.
  • Hodgkin disease recurrence risk appears lower, suggesting potential for transplantation in affected patients.

Impact:

  • Develops a comprehensive understanding of post-transplant hemopathies.
  • Informs clinical decision-making for managing these complex conditions.
  • Guides risk stratification and treatment selection for transplant recipients.