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Related Experiment Videos

Age-related decrease in serum angiotensin converting enzyme activity: the role of thyroidal status and food intake.

A D Mooradian1, J Lieberman

  • 1Department of Medicine, Sepulveda VA Medical Center.

Journal of Gerontology
|January 1, 1990
PubMed
Summary

Serum angiotensin converting enzyme (ACE) activity declines with age in rats, but this reduction is not linked to lower thyroid hormone levels or reduced food intake. This finding suggests ACE activity may not be a reliable biomarker for hypothyroidism in aging rats.

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Area of Science:

  • Biochemistry
  • Endocrinology
  • Gerontology

Background:

  • Serum angiotensin converting enzyme (ACE) activity is a key component of the renin-angiotensin system.
  • Changes in ACE activity have been observed with aging and thyroid status in various species.
  • The potential of serum ACE activity as a biomarker for hypothyroidism in aged rats requires investigation.

Purpose of the Study:

  • To determine if serum ACE activity can serve as a biomarker for tissue hypothyroidism in aging male Fischer 344 rats.
  • To investigate the relationship between aging, thyroid status, and serum ACE activity.

Main Methods:

  • Serum ACE activity was measured in rats aged 2, 6, 13, and 25 months.
  • Measurements were performed on both undiluted and diluted sera to account for ACE inhibitors.

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  • Thyroid status was manipulated using L-triiodothyronine (T3) injections and hypothyroidism induction; pair feeding was also employed.

    • Main Results:

    • Serum ACE activity significantly decreased with age, with the lowest levels observed in 25-month-old rats compared to younger groups.
    • Hyperthyroidism (T3 administration) increased serum ACE activity in older rats but decreased it in young rats.
    • Hypothyroidism did not significantly alter serum ACE activity levels across different age groups, and pair feeding did not affect baseline or stimulated ACE activity.

    Conclusions:

    • Reduced serum ACE activity in aged rats is not attributable to decreased thyroid hormone levels or reduced caloric intake.
    • Serum ACE activity does not appear to be a reliable biomarker for hypothyroidism in aging rats.
    • Further research is needed to understand the mechanisms underlying age-related changes in serum ACE activity.