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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...

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Related Experiment Video

Updated: Jun 2, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

The human proteome project: Current state and future direction.

Pierre Legrain1, Ruedi Aebersold, Alexander Archakov

  • 1CEA, France;

Molecular & Cellular Proteomics : MCP
|May 3, 2011
PubMed
Summary
This summary is machine-generated.

The Human Proteome Project (HPP) aims to map all human proteins, addressing the 30% of proteins currently unknown. This global effort uses mass spectrometry, antibody capture, and bioinformatics to advance protein research and personalized medicine.

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Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
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Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Related Experiment Videos

Last Updated: Jun 2, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
07:38

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Area of Science:

  • Proteomics
  • Human Biology
  • Genomics

Background:

  • The Human Genome Project (HGP) successfully mapped human genes.
  • Approximately 30% of human proteins remain uncharacterized.
  • A comprehensive understanding of the proteome is crucial for biological research.

Purpose of the Study:

  • To launch and coordinate the global Human Proteome Project (HPP).
  • To systematically map the entire human protein set, including abundance, localization, and function.
  • To create a comprehensive protein parts list and essential research tools.

Main Methods:

  • Utilizing mass spectrometry for protein identification and quantification.
  • Employing antibody capture techniques for protein detection.
  • Leveraging bioinformatics tools and knowledge bases for data analysis and integration.
  • Implementing a chromosome-based protein mapping strategy (C-HPP).

Main Results:

  • Establishing a global collaborative effort for proteome mapping.
  • Identifying and characterizing previously undisclosed proteins.
  • Developing a foundational dataset for human protein research.

Conclusions:

  • The HPP is essential for completing the proteome map initiated by the HGP.
  • The project will provide critical reagents and tools for protein studies.
  • Advancements in proteome knowledge will strengthen the basis for personalized medicine.
  • International collaboration and funding are vital for HPP success.