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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...

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Related Experiment Video

Updated: Jun 2, 2026

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

[Bone remodeling and glucose/lipid metabolism].

Tatsuya Yoshizawa1

  • 1Department of Medical Biochemistry, Kumamoto University.

Clinical Calcium
|May 3, 2011
PubMed
Summary

Bone is an endocrine organ regulating metabolism. Insulin signaling in osteoblasts influences bone resorption and osteocalcin activation, highlighting a key interaction between bone and glucose metabolism.

Area of Science:

  • Endocrinology
  • Metabolism
  • Bone Biology

Background:

  • Osteocalcin, secreted by osteoblasts, regulates glucose and lipid metabolism by enhancing insulin secretion and sensitivity.
  • Bone is recognized as a crucial endocrine organ influencing systemic metabolic processes.

Purpose of the Study:

  • To investigate the role of insulin signaling in osteoblasts as a regulator of bone metabolism.
  • To elucidate the mechanism by which insulin signaling in osteoblasts affects osteocalcin and bone resorption.

Main Methods:

  • The study likely involved in vitro or in vivo models to examine insulin signaling pathways in osteoblasts.
  • Analysis of osteocalcin activation and osteoclast activity in response to insulin signaling was performed.

Main Results:

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Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping

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Last Updated: Jun 2, 2026

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping
09:20

Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping

Published on: March 23, 2022

  • Insulin signaling in osteoblasts positively regulates both bone acquisition and resorption.
  • Insulin signaling in osteoblasts activates osteocalcin by stimulating osteoclast resorption activity.

Conclusions:

  • Osteoblasts are significant target cells for insulin, playing a central role in glucose/lipid metabolism.
  • The intricate bone-glucose metabolism interaction has implications for future research, particularly in clinical settings.