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Updated: Jun 2, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
High-frequency genetic contents variations in clinical Candida albicans isolates
Feng Yang1, Tian-Hua Yan, Elena Rustchenko
1Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Abstract:
Genome plasticity is a hallmark of Candida albicans and is believed to be an adaptation strategy. But the extent of such genomic variability is not well investigated. In this study, genetic contents of clinical C. albicans isolates were investigated at whole-genome level with array-based comparative genomic hybridization (array CGH) technology. It was revealed that C. albicans possessed variations of genetic contents, as well as aneuploidy. The variable genes were scattered across the chromosomes, as well clustered in particular regions, including sub-telomeric regions, retrotransposon-insertion sites and a variable region on chromosome 6.
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