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Updated: Jun 2, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Flavonoids from Daphne aurantiaca and their inhibitory activities against nitric oxide production
Shuang Liang1, Jun-Mian Tian, Yi Feng
1School of Pharmacy, Shanghai Jiaotong University, Shanghai, China.
Abstract:
Chemical examination of the methanolic extract from the stem bark of Daphne aurantiaca led to the isolation of three new flavonoids (1-3), and 29 known flavonoids. All 32 compounds were isolated for the first time from Daphne aurantiaca. The isolates were tested for inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages. Compounds 21 and 24 showed potent inhibitory activities against the production of NO with IC₅₀ values of 0.006 and 0.076 µM, respectively.
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