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Updated: Jun 2, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Temporal artery involvement in microscopic polyangitis.

Akihito Tanaka¹, Ikuko Tsujimoto, Yukiko Ito

¹Department of Nephrology, Nagoya Ekisaikai Hospital, Japan. zhangren_at_23@yahoo.co.jp

Internal Medicine (Tokyo, Japan)

|May 3, 2011

Summary

Microscopic polyangiitis (MPA) can rarely present with temporal artery involvement, mimicking temporal arteritis. Early diagnosis and consideration of MPA are crucial, especially with large vessel lesions, to prevent severe outcomes.

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Area of Science:

Rheumatology
Internal Medicine
Pathology

Background:

Temporal arteritis is a common cause of fever and temporal pain in the elderly.
Microscopic polyangiitis (MPA) is a systemic vasculitis typically affecting small vessels.

Observation:

An 81-year-old male presented with fever and temporal pain, initially diagnosed with temporal arteritis.
Further investigations revealed interstitial pneumonia and necrotizing crescentic glomerulonephritis.
Elevated myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) levels confirmed MPA.

Findings:

The patient's MPA manifested with large vessel involvement (temporal artery), atypical for this condition.
Despite initial steroid treatment for presumed temporal arteritis, respiratory symptoms worsened.

Implications:

MPA should be considered in the differential diagnosis of large vessel vasculitis, even when typical small vessel involvement is not immediately apparent.
This case highlights the importance of comprehensive diagnostic workup in complex vasculitis presentations.
Timely recognition of MPA in atypical presentations may improve patient outcomes and prevent fatal complications such as respiratory failure.