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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

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Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
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Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

Obesity, bariatric surgery, and bone.

Taraneh Soleymani1, Sirakarn Tejavanija, Sarah Morgan

  • 1Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294-3408, USA.

Current Opinion in Rheumatology
|May 3, 2011
PubMed
Summary
This summary is machine-generated.

Bariatric surgery patients often have pre-existing nutritional deficiencies impacting bone health. Comprehensive pre-surgery evaluation and post-surgery monitoring of nutrients like calcium and vitamin D are crucial for bone health management.

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Orthopedics

Background:

  • Increasing rates of bariatric surgery in morbidly obese individuals.
  • Obesity and bariatric surgery are associated with various vitamin and mineral deficiencies.
  • Current lack of consensus on bone health evaluation and management in this population.

Purpose of the Study:

  • To review nutritional deficiencies in obese and postbariatric surgical patients, focusing on bone health.
  • To discuss the relationship between adipose tissue and bone.
  • To evaluate the potential protective effect of obesity on osteoporosis.

Main Methods:

  • Literature review focusing on nutritional deficiencies and bone health in bariatric surgery patients.
  • Analysis of current findings on obesity, adipose tissue, and bone metabolism.
  • Evaluation of existing data on osteoporosis and its relation to obesity.

Main Results:

  • Nutritional deficiencies are common in postbariatric patients even before surgery.
  • Specific nutrients like calcium and vitamin D significantly impact bone health.
  • Obesity's complex relationship with bone health and osteoporosis requires further investigation.

Conclusions:

  • Pre-bariatric surgery nutritional assessment is essential to prevent nutrient depletion.
  • Monitoring calcium and vitamin D levels is critical for preventing bone loss post-surgery.
  • Standard practice includes multivitamin and mineral supplementation after bariatric surgery.