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PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism

Sri Devi Narasimhan1, Kelvin Yen, Ankita Bansal

  • 1Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

Plos Genetics
|May 3, 2011
PubMed
Summary

We identified PDP-1 as a novel phosphatase that negatively regulates the insulin/IGF-1 signaling (IIS) pathway. PDP-1 influences longevity, metabolism, and interacts with TGF-β signaling, impacting DAF-16 activity.

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