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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

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Published on: May 26, 2023

Progressive macular hypomelanosis.

Sarina B Elmariah¹, Roopal V Kundu

¹Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.

Journal of Drugs in Dermatology : JDD

|May 3, 2011

Summary

This summary is machine-generated.

Progressive macular hypomelanosis, a common skin condition in adults with darker skin tones, presents as hypopigmented patches. Antimicrobial therapy shows promise for treating this disorder, offering a new approach beyond traditional treatments.

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Published on: December 16, 2021

Area of Science:

Dermatology
Microbiology

Background:

Progressive macular hypomelanosis (PMH) is an under-recognized skin disorder affecting young adults, especially those with Fitzpatrick skin types IV-VI.
It is characterized by ill-defined hypopigmented macules and patches on the trunk, often misdiagnosed and inadequately treated.

Observation:

The exact pathogenesis of PMH remains unclear.
Recent research suggests a link between hypopigmentation and Proprionibacterium, potentially affecting melanin production and melanosome distribution.

Findings:

This study reports on five patients with PMH who showed improvement with topical and systemic antimicrobial therapy.
Antimicrobial treatment represents a potential therapeutic strategy for PMH.

Implications:

The findings support the consideration of antimicrobial therapies for progressive macular hypomelanosis.
Further research into the role of Proprionibacterium in PMH pathogenesis and treatment is warranted.